An Inequality Approach to Approximate Solutions of Set Optimization Problems in Real Linear Spaces

This paper explores new notions of approximate minimality in set optimization using a set approach. We propose characterizations of several approximate minimal elements of families of sets in real linear spaces by means of general functionals, which can be unified in an inequality approach. As particular cases, we investigate the use of the prominent Tammer–Weidner nonlinear scalarizing functionals, without assuming any topology, in our context. We also derive numerical methods to obtain approximate minimal elements of families of finitely many sets by means of our obtained results

Time-Optimal Adaptation in Metabolic Network Models

Analysis of metabolic models using constraint-based optimization has emerged as an important computational technique to elucidate and eventually predict cellular metabolism and growth. In this work, we introduce time-optimal adaptation (TOA), a new constraint-based modeling approach that allows us to evaluate the fastest possible adaptation to a pre-defined cellular state while fulfilling a given set of dynamic and static constraints. TOA falls into the mathematical problem class of time-optimal control problems, and, in its general form, can be broadly applied and thereby extends most existing constraint-based modeling frameworks. Specifically, we introduce a general mathematical framework that captures many existing constraint-based methods and define TOA within this framework. We then exemplify TOA using a coarse-grained self-replicator model and demonstrate that TOA allows us to explain several well-known experimental phenomena that are difficult to explore using existing constraint-based analysis methods. We show that TOA predicts accumulation of storage compounds in constant environments, as well as overshoot uptake metabolism after periods of nutrient scarcity. TOA shows that organisms with internal temporal degrees of freedom, such as storage, can in most environments outperform organisms with a static intracellular composition. Furthermore, TOA reveals that organisms adapted to better growth conditions than present in the environment (“optimists”) typically outperform organisms adapted to poorer growth conditions (“pessimists”)

Time-Optimal Adaptation in Metabolic Network Models

Analysis of metabolic models using constraint-based optimization has emerged as an important computational technique to elucidate and eventually predict cellular metabolism and growth. In this work, we introduce time-optimal adaptation (TOA), a new constraint-based modeling approach that allows us to evaluate the fastest possible adaptation to a pre-defined cellular state while fulfilling a given set of dynamic and static constraints. TOA falls into the mathematical problem class of time-optimal control problems, and, in its general form, can be broadly applied and thereby extends most existing constraint-based modeling frameworks. Specifically, we introduce a general mathematical framework that captures many existing constraint-based methods and define TOA within this framework. We then exemplify TOA using a coarse-grained self-replicator model and demonstrate that TOA allows us to explain several well-known experimental phenomena that are difficult to explore using existing constraint-based analysis methods. We show that TOA predicts accumulation of storage compounds in constant environments, as well as overshoot uptake metabolism after periods of nutrient scarcity. TOA shows that organisms with internal temporal degrees of freedom, such as storage, can in most environments outperform organisms with a static intracellular composition. Furthermore, TOA reveals that organisms adapted to better growth conditions than present in the environment (“optimists”) typically outperform organisms adapted to poorer growth conditions (“pessimists”).Peer Reviewe

An Inequality Approach to Approximate Solutions of Set Optimization Problems in Real Linear Spaces

This paper explores new notions of approximate minimality in set optimization using a set approach. We propose characterizations of several approximate minimal elements of families of sets in real linear spaces by means of general functionals, which can be unified in an inequality approach. As particular cases, we investigate the use of the prominent Tammer–Weidner nonlinear scalarizing functionals, without assuming any topology, in our context. We also derive numerical methods to obtain approximate minimal elements of families of finitely many sets by means of our obtained results

Cross-cultural differences in a global "survey of world views"

We know that there are cross-cultural differences on psychological variables, such as individualism/collectivism. But it has not been clear which of these variables show relatively the greatest differences. The Survey of World Views project operated from the premise that such issues are best addressed in a diverse sampling of countries representing a majority of the world’s population, with a very large range of item-content. Data was collected online from 8,883 individuals (almost entirely college students based on local publicizing efforts) in 33 countries that constitute over 2/3 of the world’s population, using items drawn from measures of nearly 50 variables. This report focuses on the broadest patterns evident in item data. The largest differences were not on those contents most frequently emphasized in cross-cultural psychology (e.g., values, social axioms, cultural tightness), but instead on contents involving religion, regularity-norm behaviors, family roles and living arrangements, and ethnonationalism. Content not often studied cross-culturally (e.g., materialism, Machiavellianism, isms dimensions, moral foundations) demonstrated moderate-magnitude differences. Further studies are needed to refine such conclusions, but indications are that cross-cultural psychology may benefit from casting a wider net in terms of the psychological variables of focus